4月20日美国明尼苏达大学Changquan Calvin Sun教授学术报告预告

    Title：The Materials Science Tetrahedron for Successful Drug Product Development
    Time: 10:15 a.m., April 20, 2017
    Place: international conference hall, Run Run Shaw Building, Zhaohui Campus, Zhejiang University of Technology
    Speechmaker: Changquan Calvin Sun
    

    Dr. Sun is currently an associate professor of Pharmaceutics and Director of Graduate Studies at the Department of Pharmaceutics, University of Minnesota. He was a visiting professor at University of Copenhagen, Denmark, from July 2014 to July 2015. After receiving his Ph.D. in Pharmaceutics from the University of Minnesota in 2000, he worked in the pharmaceutical industry (Pharmacia/Pfizer and Amgen) during 2000 – 2008. Dr. Sun joined the University of Minnesota as an assistant professor in 2008 and was promoted to the current position in 2013.
    Dr. Sun’s research focuses on formulation development of tablet products through appropriate application of materials science and engineering principles, including 1) crystal and particle engineering for superior powder flow and compaction properties; 2) understanding and control of common pharmaceutical unit operations, e.g., blending, granulation, and tableting. Dr. Sun is an expert in the areas of solid-state science, tablet formulation design, and powder technology. He has published bbin电子 than 100 peer-reviewed papers in these areas.
    Dr. Sun currently serves on the editorial boards for J. Pharm. Sci., Int. J. Pharm., and Tablets and Capsules. He is a member of Expert Committee in Physical Analysis, United States Pharmacopeia. Dr. Sun was elected an AAPS Fellow in recognition of his sustained level of superior and distinguished professional achievement and contributions in Pharmaceutical Sciences.
    Abstract: The manufacturing of pharmaceutical products is commonly faced with problems when formulation and process are not robust. Historically, this problem arises from empirical product development to address the challenge of diverse API properties. The materials science tetrahedron (MST) principle can be applied to guide the development of a robust process for manufacturing high-quality drug product.(1) The effort starts with developing a clear understanding of the structure-property-performance relationship, which forms a materials science triangle. On this basis, engineering solution naturally arrives to address problems at molecular, crystal/particle, or bulk solid levels as appropriate. In this talk, I will first explain the concept of MST and its potential application in pharmaceutical product development. This will be followed by examples of solving tablet manufacturing problems, through crystal and particle engineering, following the MST principle.