7月20日郭诤教授学术讲座预告

　　报告题目：Molecular basis and chemical essence of Macromolecular scaffolds catalyzed carbon-carbon bond formation – Non-protein enzymology, enzyme biofluids and enzyme promiscuity大分子催化碳碳合成的分子基础和化学本质——非蛋白生物催化，酶生物流体及酶中劈腿族
　　讲座时间：2016年7月20日（星期三）15:00—16:30
　　讲座地点： 邵科馆一楼圆廊
　　主讲人：郭诤
　　主讲人简介：
　　郭�，曾任丹麦工业大学助理教授，现任丹麦奥胡斯大学副教授(终身职位)，脂质材料与生物催化领域专家，他领导的农业生物技术科学团队（Agro-Biotechnolgy Science Group）参与和领导丹麦独立研究基金，高科技基金多项（过去5年项目共享总额达一千一百万欧元），并与诺�S信，葛兰素史克，杜邦等国际大公司合作承担多个大型研究项目，在国际化工和生物催化领域权威期刊上发表研究论文逾100篇，现为2个国际期刊编委，Elsevier出版专著一部，获美国和世界专利授权4项。
　　讲座内容摘要：
　　Biocatalysis is generally recognized as a concept of the function by protein-based scaffolds (enzymes); while other macrobiomolecules such as Ribonucleic acid (RNA) and Deoxyribonucleic acid (DNA) are understood to be a messenger or a carrier of genetic information. RNA/DNA was found to be able to function as a biocatalyst to catalyze carbon-carbon bond formation reaction. The mechanism of enzyme catalysis is based on stereo- or configuration recognition by fine macromolecular architecture (pro-stereogenic element); and functional groups (around active site of enzyme) assisted formation of transition state by formation of enzyme-substrate complex. Other macromolecules are rich of a variety of functional groups that are able to provide interaction of H-bonding, coordinating and π-π interactions etc. and these groups (basic unit as nucleotides) are organized as single- or double- stranded with unique three-dimensional structures that are capable of affording stacking interactions.
　　In this talk, the new progresses in natural macromolecules mediated organic synthesis, particularly in carbon-carbon bond formation is overviewed. The understanding of the molecular basis and chemical essence of enzyme/non-enzyme macromolecules for biocatalysis is presented. Our efforts in mining novel promiscuity and design of hydrolases for carbon-carbon bond formation reactions are highlighted. The perspective of biocatalysis for future applications in green synthesis, biorefining, food and pharma industries will be previewed.
　　Enzyme-polymer surfactant nanoconjugates entail a new form of enzymes: enzyme biofluids, which the enzyme exists as solvent-free melts. Most interestingly, this self-contained reactive biofluid is able to retain catalysis activity at elevated temperature up to 150°C or even higher. This is higher than any ever reportedthermophilic enzyme. This will dramatically change the concept of enzyme biology and challenge the existing paradigm on the role of water molecules in protein folding and function, and will offer huge opportunity for biocatalysis and biotransformation for synthesis purpose.