8月29日“绿色制药前沿论坛”第三十五讲预告

题目：A fight against breast cancer: New insights from a brain metastatic variant of human breast cancer cell lines

主讲人：Dr. Yoshinori Kato， Hoshi University (日本星药科大学) 

时间：2018年08月29日（星期三）10:00-11:00

地点：新教1006室

讲座内容简介（Abstract）：

Breast cancer poses physical and emotional problems for patients becausebreast cancer cells are prone to metastasize to other organs and to acquire resistance to multiple drugs.  The lymph nodes, lungs, bones, liver, and brain are the common metastatic sites for breast cancer patients, and this aggressive metastatic behavior negatively affects the overall survival of breast cancer patients, especiallytriple-negative breast cancer(TNBC) patients.Some of the reasons for such poor prognosis include inoperability due to the systemic dissemination of breast cancer cellsand refractoriness to chemotherapy.Although it is important to understand intrinsic drug resistanceof metastatic cancer cells as cancer metastasis occurs even before chemotherapy, little is known about such refractoriness in metastatic breast cancer cells.In addition,whileTNBC patients generally have a poor prognosis, some of themstill show a relatively better prognosis.  Therefore, better management of TNBC patients can be achieved by a routine follow-up using prognostic biomarkers easily detectable in the blood.Among the proteinsoverexpressed in a frequently used brain metastatic phenotype of human breast cancer cell line, MDA-MB-231BR, we identifiedtwoproteinsthat played a key role in drug resistance of breast cancer cells metastasized to the brainand aggressiveness of TNBC.

This presentation will cover: i) intrinsic drug resistance in a brain metastatic phenotype of human breast cancer cell line; and ii) the development of prognostic biomarker for triple-negative breast cancer.A better understanding of metastatic breast cancer cells may provide a helpfulclue to a fight against breast cancer.

主讲人简介：

Dr. Yoshinori Kato obtained his bachelor’s , master's degree and phD study  in Hoshi University(Japan), his title of phD Thesis is "Potentialities of N-Succinyl-chitosan as a Drug Carrier for Water-soluble Macromolecular Prodrugs".  After completion of his Ph.D. in Pharmaceutics, he has been Postdoc for Hoshi university for one year. Later he spent three years in Johns Hopkins University, Baltibbin电子, USA for Postdoc, which is bbin电子 focused on Cancer molecular imaging. Now he is an Associate Professor, Laboratory of Biofunctional Science, Hoshi University School of Pharmacy and Pharmaceutical Sciences (Tokyo, Japan) .