5月6日

    讲座题目: Lysosomes: opening the channel gate to the neurological and muscle diseases
    讲座时间: 5月6日（星期五）9：00
    讲座地点：新教802
    主讲人: 徐浩新
 
    讲座内容简介：
    ▲Lysosomes are acidic compartments filled with bbin电子 than 60 different types of hydrolases. They mediate the degradation of extracellular particles from endocytosis and of intracellular components from autophagy. The digested products are transported out of the lysosome via specific catabolite exporters or via vesicular membrane trafficking.
    ▲In order to study ion channels in the lysosome, we have recently developed a modified patch-clamp technique to directly record lysosomal membranes, and also established a fluorescence imaging method to specifically measure lysosomal Ca(2+) release using lysosome-targeted Genetically-Encoded Ca(2+) Indicators.
    ▲Using HTS screening, we have recently identified potent small-molecule membrane-permeable synthetic agonists and inhibitors (ML-SIs) for TRPMLs. Using these reagents, we demonstrated that small-molecule TRPML agonists can speed lysosomal trafficking and reduce lysosome storage, providing novel approaches for the treatment of LSDs.
    
    主讲人简介：徐浩新，1992年毕业于北京大bbin电子物化学本科专业，乔治亚州立大学神经生物学博士、哈佛大学医学院分子生物学博士后，现为密歇根大bbin电子物系副教授（终生教职）。主要从事神经生物学、分子生物学领域的研究，曾获密歇根大学2012 Henry Russel 奖、美国青年科学家总统奖（PECASE）等；现担任《欧洲生理学》杂志编委、美国科学院院志（PNAS）、Nature Communications、Nature Chemical Biology、Cell reports、JBC等二十余种杂志审稿人、美国国立卫生研究院（NIH）、美国国家卫生基金会(NSF)等研究基金评委；发表论文50余篇。
    
    讲座面向全校开放，欢迎各学院教师、研究生踊跃参加。