12月3日“绿色制药前沿论坛”第十七讲预告

　　题  目：Palladium Chemistry in Biological Systems （在生物系统内发生的钯化学）
　　时  间：12月3日（星期四）15：30
　　地  点：朝晖校区新教1006
　　主讲人：Prof. Mark Bradley （英国爱丁堡大学）
    
　　讲座内容简介：
　　Pioneering studies have demonstrated the synthetic potential of palladium-mediated cross-coupling reactions in chemical biology. In my talk the scope of palladium-mediated chemistry will be described and its extension into in vivo systems, where polymeric solid supports are functionalised with palladium nanoparticles and used as biocompatible, heterogeneous catalysts in selective de-caging and cross-coupling reactions. In order to gain tumour selectively, targeting functionalities have been incorporated into the particles to allow the spatial control of the selective activation of labelling probes, as well as pro-drugs activation and in situ drug synthesis （Ref: Nature Chem 2012, Nature Protacols 2013 and Nature Commun 2014）.
    
　　主讲人简介：
　　Professor Bradley’s independent career began in 1992 when he joined the University of Southampton as a Royal Society University Research Fellow (1992-1999). He was awarded a personal chair in Combinatorial Chemistry at the age of 34 and in 1997 founded the Centre for Combinatorial Chemistry. In 2005 he took up his current position at the University of Edinburgh. His work is focused on the application of chemistry to solving medical problems (chemical medicine). His group has published bbin电子 than 20 patents and 300 articles in the form of papers, reviews and book. Professor Bradley is the recipient of numerous international awards and prizes including the Novartis lectureship (2007 - USA, Switzerland, Japan and UK), election to fellowship of the Royal Society of Edinburgh and in 2010 he was made a fellow of the Royal Society of Chemistry. He was awarded the 2009 prize of the Society of Combinatorial Sciences and in 2011 was honored with the Chancellors Award (the highest research award of the University of Edinburgh). In 2012 he was awarded an honoree Professorship by Changzhou University, China.
　　Three research themes dominate in his group at this time:
　　(i). The development and exploitation of polymer microarray technology for the identification and application of polymers for controlling and modulating cells.
　　(ii). The development of “smart” fluorescent reporters for in vivo based optical molecular imaging.
　　(iii). In vivo catalytic chemistry.
　　He was co-founder of Ilika Technologies (2004) which floated on AIMS in 2010. In 2010 he was a co-founder of the spin-out DestiNA Technologies (which raised £1.2M of corporate investment in July 2014) and in March 2014 he was a founder of Edinburgh Molecular Imaging which raised £4M series A investment.
    
　　讲座面向全校开放，欢迎各学院教师、研究生、本科生等踊跃参加。